Furthermore, the insulin-like growth factor 1 (IGF-1) has been shown to trigger TLR9 expression in glioma cells through activation of hypoxia-induced factor 1 alpha signaling, which in turn stimulates IL-1β, IL-6, IL 8 as well as CXCR4 [17,44]. The gene discussed is TLR9; the disease is central nervous system cancer.