Monocytes express a wide range of PRPs including TLRs, NLRs, RLRs and CLRs which in glioma TME enable immunosuppression (through IL-10 and TGF-β cytokine release), fuel inflammation (through the secretion of IL-1β and IL-18) and preserve tumor growth (through VEGF, MMPs, and IL-1β expression) [113,114,115,117,118,119,120]. This evidence concerns the gene VEGFA and central nervous system cancer.