We have conducted a focused search of the literature in the PubMed, Scopus, and Web of Science databases, using different combinations of keywords such as “glioma” or “glioblastoma” with “innate immune receptors”, “innate immunity”, “TLR”, “NLR”, “cGAS-STING”, “RIG-I”, “CLR” and “scavenger receptor”. Here, CGAS is linked to glioma.