Moreover, the activation of NLRP3 inflammasome activation results in IL-1β secretion enhancing glioma progression but also recruiting NK cells which can be further activated by type I interferons through RIG-I/MDA5 signaling [123], indicating that innate immune receptors may induce both activation as well as suppression of NK cells in glioma TME. This evidence concerns the gene IFIH1 and central nervous system cancer.