Experimental studies in IGF-1-deficient or IGF-1-depleted animal models consistently show an increased burden of CMBs [32,33,38], impaired autoregulatory function [121,192] and neurovascular uncoupling [193], pathological structural adaptation to hypertension [186,194] and heightened vulnerability to hemorrhagic injury [38]. This evidence concerns the gene IGF1 and hypertensive disorder.