Consistent with this mechanism, ALD-R491 has been shown to remodel the vimentin interactome [26], reduce the motility of cells and the release of intercellular communication mediator exosomes [27], and exert host-directed anti-bacterial, anti-viral, and anti-inflammatory effects [23,28], all of which are closely relevant to sepsis pathology. The gene discussed is VIM; the disease is Sepsis.