The pathophysiological mechanisms linking albuminuria to HF are multifactorial, encompassing glomerular injury, systemic endothelial dysfunction, low-grade inflammation, neurohormonal activation—particularly of the renin–angiotensin–aldosterone system (RAAS) causing directly podocyte injury—and elevated central venous pressure leading to renal congestion [57,58]. This evidence concerns the gene REN and hydrops fetalis.