The present study explored the hepatoprotective potential of three natural compounds, quercetin, silibinin, and crocetin, on MASLD, focusing on their effects on histopathological severity and the modulation of CD36 and PLIN3 expression, that play a pivotal role in hepatic steatosis and lipids metabolism [37,42]. The gene discussed is CD36; the disease is metabolic dysfunction-associated steatotic liver disease.