MANF and Alzheimer disease: Further, the Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) acts as a protective factor in cellular stress against tau hyperphosphorylation; finally, Selenoprotein P (SELENOP) is a protein content selenium, expressed in glial cells and involved in the sensibility to ferroptosis, whose low levels promote oxidative stress in the AD brain [50].