As a diagnostic biomarker, recent studies have shown that urinary soluble CD163 has the following good ROC parameters (AUC 0.76–0.97, Sn 85%, Sp 100%, PPV 84.7%, NPV 100% vs. non-renal SLE/inactive SLE; AUC 0.90–0.97 vs. healthy controls) [86,94]. This evidence concerns the gene CD163 and systemic lupus erythematosus.