More than 700,000 G4 motifs were recognized in human cancerous cells [21,22], highlighting the presence of G4-forming sequences at the Transcription Start Sites (TSSs) of genes related to cancer, such as c-MYC, BCL-2, KRAS, c-KIT, and VEGF [12,23,24,25,26], and apart from the assessed role of G4 inside human cells, their relevance can also be linked to their presence in other biological environments, including viruses [27], bacteria [28], and other parasites [29], making them a useful and versatile target to gain insight into its pharmacological effects towards infections. The gene discussed is MYC; the disease is cancer.