Comparable findings in myeloid leukemias were reported by Halici et al. and Obeidat et al., showing that both purified melittin and bee venom extracts significantly reduced K-562 cell survival by inducing apoptosis and cell cycle arrest, along with regulation of apoptosis- and proliferation-related genes such as ABL1, JUN, TNF, c-MYC, and CDK4 [30,31]. This evidence concerns the gene CDK4 and myeloid leukemia.