ALKBH5 and non-small cell lung carcinoma: In contrast, elevated ALKBH5 demethylase activity reduces global m6A levels and improves stabilization of oncogenes (MYC, SOX2, and SMAD7) with the ALKBH5–m6A–YTHDF2 axis, driving an aggressive phenotype in KRAS-mutant NSCLC (Figure 1) [32].