Moreover, METTL3 upregulation in BC tissues and cell lines impacts uncontrolled proliferation and invasion, and suppresses apoptosis by stabilizing Bcl-2 mRNA and affecting the MALAT1/miR-26b/HMGA2 axis, contributing to the development of adriamycin (ADR) chemoresistance via miR-221-3p/HIPK2/Che-1 pathway (Figure 2) [24,40,41]. This evidence concerns the gene METTL3 and breast cancer.