They found that in MDA-MB-231 xenograft mice, C. minima extract could significantly reduce cell viability and proliferation in a dose-dependent and time-dependent manner, induce apoptosis, and inhibit cancer cell migration and invasion, and exert its anti-triple-negative breast cancer effects through multi-targets and multi-pathways, such as the EGFR, PI3K/AKT/mTOR, NF-κB, and STAT3 pathways, and cause a decrease in MMP-9 activity and metastasis inhibition in vitro, without any side-effects. This evidence concerns the gene STAT3 and cancer.