Our findings parallel those reported in the recent study by da Silva et al. [45], who demonstrated that extracellular vesicles released from DC, particularly when primed with S. brasiliensis, conferred significant protection against experimental sporotrichosis, reducing fungal load and promoting cytokine responses characterized by increased IFN-γ, TNF-α, IL-17, and IL-10. This evidence concerns the gene IL10 and sporotrichosis.