CD40LG and Acute hepatitis: Based on our results, we demonstrate the need for raising awareness among healthcare providers about HEV as a more common cause of acute hepatitis in Romania, and for availability of efficient tests for an accurate diagnosis of hepatitis E (i.e., serological assays with improved sensitivity for anti-HEV IgM antibodies, easier access to HEV-RNA tests, and serological assays for anti-HEV IgG antibodies in those cases where the diagnosis needs clarification).