For example, lncRNA CASC2 can act as a “sponge” for miR-24 and miR-221, regulating caspase-3/8 (CASP3/8) to affect TNF-related apoptosis-inducing ligand (TRAIL) resistance in hepatocellular carcinoma [10]. This evidence concerns the gene TNFSF10 and hepatocellular carcinoma.