The results found in this study, indicating a higher expression of NGF in lesions of leprosy patients with multibacillary forms, corroborate studies that compared the expression of NGF among leprosy patients with different clinical forms of the disease, with a higher expression of neurotrophin in patients with multibacillary forms [35,47], indicating an attempt to promote greater neuroprotection by increasing neurotrophin expression and consequent tissue remodeling and regeneration [27,48,49]. This evidence concerns the gene BDNF and leprosy.