Analyzing the expression of NGF only in the group of leprosy patients with HIV, it was observed that this was more relevant in multibacillary clinical forms, especially among those who used HAART and who were diagnosed with leprosy in the period suggestive of immune restoration (in the first six months after starting therapy), which corroborates the assumption that immune restoration favors neurotrophin production [53,56]. Here, BDNF is linked to leprosy.