TREM1 and infection: Nevertheless, the combination of the transcriptomic, in vitro, and in silico results presented here strongly suggest that TREM-1 might be an important player in RV infection and pathogenesis, possibly acting in the physiopathology of this infection through the recognition of viral proteins, like the NSP4 enterotoxin, and as a coreceptor for the cell entry process, thus being a promising biomarker candidate for infection diagnosis and prognosis and a target for therapeutic interventions.