For the children’s dataset, we observed the overlap of the healthy and “RV 4–8” group (patients on days 4–8 after disease onset) but an overall distance between the “RV 1–3” group and both the healthy and “RV 4–8” groups, indicating that TREM1 expression is time dependent and predominantly higher during the first three days of infection (Figure 1k). Here, TREM1 is linked to infection.