TREM1 and infection: For the child dataset, the pattern was more subtle, but there were several genes notably increased in children on days 1–3 post-infection (RV days 1–3), including TREM1 and its adaptor protein, DAP12 (TYROBP gene), many pattern recognition receptors, transcription factors, pro-inflammatory cytokines, and caspases (highlighted in red, Figure 1i).