IL-10 can also induce M2 differentiation by regulating other cytokines (suppressing TNF-a/IL-6 while enabling IL-4 secretion [122]) and through feedback loops (particularly in the pathological macrophage polarization of polycystic kidney disease, where autocrine IL-10 sustains this self-reinforcing cycle [123]). The gene discussed is IL10; the disease is polycystic kidney disease.