NRGN and gonorrhea: We show here that a combination MenB NOMV vaccine component (Nm NOMV) with overexpressed mutant FHbp from Subfamilies A and B provides broader coverage and higher serum bactericidal activity (SBA) against MenB than existing MenB vaccines and, when combined with Ng NOMV components (Nm-Ng NOMV), elicits antibodies with broad SBA against MenB and Ng strains and inhibits the colonization of Ng in human cervical and vaginal cell lines and in a transgenic mouse model of gonorrhea.