TNFSF13B and chronic kidney disease: These findings indicate that VAT-induced inflammation, adipokine imbalance, BAFF/APRIL signaling, intestinal dysbiosis, and oxidative stress coincide with histopathological abnormalities to accelerate IgAN progression, moreover, circulating biomarkers of inflammation and tubular repair have been associated with CKD progression and may refine risk in IgAN [6].