Obesity-associated intestinal dysbiosis disrupts the gut-kidney axis, activating GALT and increasing Gd-IgA1 production [5,47], while BAFF/APRIL overexpression links adipose tissue inflammation with increased B cell activation and complement deposition [8,26,27,43,44,48]. The gene discussed is IGHA1; the disease is obesity due to melanocortin 4 receptor deficiency.