VEGFA and neoplasm: Researchers have conducted extensive investigations into the antitumor mechanisms of BJO and BJOE, which include the induction of apoptosis, disruption of the cell cycle, interference with cellular energy metabolism, inhibition of VEGF expression, suppression of tumor proliferation, reversal of drug resistance, enhancement of chemotherapy efficacy, reduction in drug toxicity and side effects, and delay of tumor progression [143,144,145,146].