The proinflammatory cytokine factor (Factor 1) was significantly associated with increased insulin resistance and reduced insulin sensitivity, reflected by higher HOMA-IR (β = 0.45; p = 0.007) and lower Matsuda index scores (β = –0.43; p = 0.009), indicating that greater proinflammatory activity was linked to worsening insulin function. The gene discussed is INS; the disease is Insulin resistance.