ND6 mtDNA DAMPs (logND6) were associated with greater insulin resistance (HOMA-IR: β = 0.90; SE = 0.40; p = 0.03) and lower insulin sensitivity (Matsuda index: β = −0.86; SE = 0.33; p = 0.01), explaining 64% and 49% of the variance in each outcome, respectively. This evidence concerns the gene INS and Insulin resistance.