In the two more recent, larger metanalysis including 28 studies (5976 infertile males and 5774 controls) [79] and 46 studies (20,639 participants) [80], respectively, no significant association was observed between the MTHFR 1298A>C polymorphism and male fertility, neither considering fertile vs. infertile men, nor normospermic vs. dyspermic subjects. The gene discussed is MTHFR; the disease is Infertility.