Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) is an anchor protein of LPL in the vascular endothelium, and autoantibodies against GPIHBP1 can decrease the LPL activity levels to cause hypertriglyceridemia [13]. This evidence concerns the gene GPIHBP1 and hypertriglyceridemia.