KEGG pathway enrichment highlighted endocrine resistance, fluid shear stress and atherosclerosis, chemical carcinogenesis—reactive oxygen species, proteoglycans in cancer, relaxin/prolactin signaling, focal adhesion, and diabetic cardiomyopathy—pathways that converge on PI3K/AKT nodes (Figure 3D). The gene discussed is PRL; the disease is diabetic cardiomyopathy.