Interestingly, recent reports suggest that the neuroinflammatory processes, with proinflammatory cytokine release and activation of receptors such as high mobility group box 1 (HMGB1), tumor protein P63, and signal transducer and activatior of transcription 3 (STAT3), are similar to those seen in various neurological conditions, including autism, cerebral palsy, depression, Alzheimer’s disease, and neuromyelitis optica [53]. This evidence concerns the gene HMGB1 and major depressive disorder.