Similarly, no significant differences were observed between groups for other major comorbidities, including chronic rhinosinusitis with nasal polyps, obstructive sleep apnea syndrome (OSAS), gastroesophageal reflux disease, urticaria, psoriasis, aspirin/NSAID hypersensitivity, bronchiectasis, food allergy, eosinophilic granulomatosis with polyangiitis (EGPA), or alpha-1 antitrypsin deficiency. This evidence concerns the gene PSMA6 and chronic rhinosinusitis.