HMGB1 and Feingold syndrome: Assemble compact panels combining inflammatory (IL-1β, IL-6, TNF-α, HMGB1), metabolic (HbA1c, HOMA-IR, lipid fractions, AGEs), hormonal (estradiol, SHBG, thyroid function) and vascular markers (NO metabolites, ADMA, ICAM-1/VCAM-1) to classify FS subtypes by systemic dysfunction rather than symptoms alone.