APOH and Stroke: The study revealed several key findings: (1) hematologic involvement predominantly occurred within the first three years after disease onset; (2) splenomegaly was significantly associated with serositis, lupus anticoagulant, and anti-β2GPI IgG positivity; (3) lymphadenopathy was more frequent in patients with cutaneous vasculitis and lupus nephritis; and (4) mortality was associated with stroke, anti-histone antibodies, and high steroid use, while remission favored patients with fewer comorbidities.