In a study by Tassone et al. [32], treatment with Metformin led to a 45% reduction in tumor volume, a 1.8-fold increase in apoptotic cells, and a 28% decrease in monocarboxylate transporter 1 (MCT1) expression—an importer of lactate associated with the reverse Warburg effect. The gene discussed is SLC16A1; the disease is neoplasm.