Cell infection and transfection to generate lentivirus expressing shDNMT1/RNA extraction and RT-qPCR/LncRNA Microarray analysis/WB/Proliferation assay/Annexin-V/PI Double staining for apoptosis analysis/Tumor xenograft in nude mice/RNA RIP/MSP/SAHH activity assay. Here, ANXA5 is linked to neoplasm.