Because this is a Perspective rather than a systematic review, we conducted a targeted scoping search of PubMed/MEDLINE, Embase, and Cochrane Central (Jan 2020–Sept 2025; last update Sept 2025) using combinations of: residual risk, LDL, apoB, triglycerides, remnant cholesterol, psychosocial stress, MSIMI, Takotsubo, microvascular dysfunction, NLRP3, endothelial dysfunction, β-blocker titration, wearables, HRV, JITAI, CBT, MBSR, Mediterranean diet, fermented foods, microbiome, SCFAs, nutritional psychiatry. Here, NLRP3 is linked to endothelial dysfunction.