Prospective studies in 15 patients have shown that the stabilization of HIF-1α [16] and HIF-2α in patients with GER [51] under hypobaric hypoxia is associated with oxidative stress and inflammatory molecules [52], which may support the association between hypobaric hypoxia and GER through oxidative stress and proinflammatory proteins. This evidence concerns the gene EPAS1 and gastroesophageal reflux disease.