Enjalbert et al. (2020) [86] employed CRISPR/Cas9 gene editing to generate a knockout (KO) cell line for the ABCA12 gene to investigate the pathological mechanisms of Harlequin Ichthyosis (HI), a severe skin disease caused by loss-of-function mutations in ABCA12. The gene discussed is ABCA12; the disease is Harlequin ichthyosis.