Indeed, tumor exosomes often carry immunosuppressive molecules such as PD-L1, TGF-β, FasL, miRNAs, and others, which can inhibit T-cell activation, promote regulatory T cells, induce apoptosis of effector cells, or polarize myeloid cells toward suppressive phenotypes (e.g., M2 macrophages) [23]. The gene discussed is CD274; the disease is neoplasm.