Our analysis of publicly available gene expression data is consistent with previous studies reporting upregulation of glycolytic enzymes GPI [105], ALDOA [106], GAPDH [107,108], PKM [108,109], LDHA [110,111], PGAM1 [112], and ENO1 [113], as well as downregulation of ALDOC [114], while it was first to discover upregulation of ENO2, PGK1, TPI1, PFKL, and HK3 and downregulation of ENO3 in skin melanoma patients. This evidence concerns the gene HK1 and cutaneous melanoma.