CTSC and cancer: Thus, its higher abundance in fibroblasts and the resulting increased formation of membranolytic LLOMe polymers may override the greater lysosomal membrane stability of fibroblasts, leading to the release of upregulated cathepsin B. Accordingly, monocytes were shown to be more sensitive than tumor cells to LLOMe due to their higher cathepsin C expression [31], arguing against its therapeutic applicability in cancer.