Several cytotoxic mechanisms on cancer cells were described: ferroptosis caused by HO• accumulation from H2O2 induced by Fe(II) in acidic cancerous medium; inactivation of glutathione peroxidase 4 (GPX4); OS augmentation and enhancement of ferroptosis as additional effects of Pt(IV)-reduction to Pt(II) complexes; inhibition of angiogenesis resulting from lower levels of vascular endothelial growth factor-A (VEGF-A); mitochondrial damage and affected angiogenesis caused by the exposed selenium core [61]. This evidence concerns the gene GPX4 and cancer.