XX male syndrome, also known as 46,XX testicular Disorder of Sex Development (DSD), is a rare condition in which individuals with a typically female chromosomal pattern (46,XX) develop male physical characteristics, often due to the presence of the Sex-determining Region Y protein (SRY gene)-normally found on the Y chromosome- translocated onto one of the X chromosomes [56]. The gene discussed is SRY; the disease is disorder of sexual differentiation.