TGFB1 and idiopathic interstitial pneumonia: Further research on the Gas6/TAMs axis in IPF development is warranted as M2-like macrophages are dominant in later stages of fibrosis, secreting pro-fibrotic mediators such as TGF-β1 and platelet-derived growth factor (PDGF) that promote fibroblast activation and collagen deposition [69].