In the RNA-seq data, high PUM1 expression was significantly associated with young age (p = 0.0074), negative lymph nodes (p = 0.0034), tumor grade 2 (p < 0.0001), ER+ (p = 0.0084), PR+ (p < 0.0001), and HER2− (p < 0.0001; Figure 3). This evidence concerns the gene ESR1 and neoplasm.