CGAS and cancer: In this context, cancer cells undergoing treatment-induced stress responses release several endogenous molecules that function as adjuvants, including adenosine 5′-triphosphate (ATP), a downstream product of the autophagy process; calreticulin (CALR), a downstream product of endoplasmic reticulum stress; and type I interferon (IFN), a downstream product of Toll-like receptor 3 (TLR3) or cyclic GMP-AMP synthase signaling [273].