Several secretory factors such as cytokines (IL-6, IL-10 and IL-11, IL-12, GM-CSF and TNF-α), chemokines CXCL-8, CXCL-10, CXCL12 and CCL-3 and growth factors VEGF and TGF-β are important roles in tumor cell invasion and infiltration [131,132]. Here, IL6 is linked to neoplasm.