In a mouse model of PC driven by mutant KRAS/p53 [doxycycline-inducible Kras G12D and Trp53 R172H under the control of pancreatic transcription factor 1 (Ptf1), Cre recruiter], the depletion of CD11b+ myeloid cells resulted in the expansion of intratumoral CD8+ T cells [188]. This evidence concerns the gene KRAS and pachyonychia congenita.