VKORC1 and androgen insensitivity syndrome: We previously investigated the implication of CYP4F2 and VKORC1 polymorphisms in carotid plaque formation and risk of AIS, and we showed that polymorphisms in the VKORC1 and CYP4F2 genes might increase the probability of plaque carotid formation and may increase the risk of AIS in patients without a determined embolic source [13,14].