GEA, a natural compound derived from Garcinia hanburyi, targets CIP2A [133] by inducing CIP2A degradation via the ubiquitin–proteasome pathway, disrupting oncogenic signaling pathways like MYC and phosphorylated Akt and enhances the sensitivity of hepatocellular carcinoma cells to anticancer agents [133]. This evidence concerns the gene CIP2A and hepatocellular carcinoma.