Similarly, in the recent effect of short Duration of DAPT followed by Dose reduction after Implantation of DCS in ACS patients (4D-ACS) trial involving patients with acute coronary syndrome, we demonstrated that early discontinuation of aspirin, followed by P2Y12 inhibitor monotherapy, led to a marked reduction in bleeding events, most of which were gastrointestinal [16]. Here, P2RY12 is linked to acute coronary syndrome.