Conversely, in RYGB individuals, ghrelin levels were 77% lower than in controls and 72% lower than in matched controls with obesity, despite a 36% weight loss, with no normal food-related diurnal fluctuations, indicating a lasting suppression of ghrelin secretion linked to the surgical bypass of ghrelin-producing cells in the fundus [36]. Here, GHRL is linked to obesity due to melanocortin 4 receptor deficiency.