Specifically, Grade 3 TRAEs included alanine aminotransferase (ALT) increase (4.7%), diarrhea (3.9%), anemia (3.1%), aspartate aminotransferase (AST) increase (2.3%), blood alkaline phosphatase increase (1.6%), hepatitis (0.8%), lymphocyte count decrease (0.8%), gamma-glutamyl transferase increase (0.8%), and hyponatremia (0.8%). The gene discussed is GPT; the disease is anemia (phenotype).