The specific study objectives include determining (i) the clinicopathological features of NTRK gene expression in CRC, (ii) the molecular/genomic correlates of NTRK gene expression in CRC and (iii) the mechanisms of NTRK1/2/3 expression deregulation in CRC; assessing (iv) the enrichment and activation of NTRK1/2/3 signalling in CRC; and investigating (v) the potential for NTRK1/2/3 expression to predict kinase inhibitor response in CRC. Here, NTRK1 is linked to colorectal carcinoma.