Specifically, pathway ontology enrichment (KEGG 2021 Human) demonstrated that MAPK, PI3K-Akt, neurotrophin, JAK-STAT, Ras and TGF-beta signalling pathways, among others, were overrepresented in the NTRK1-high subset of both CRC cohorts but not in the NTRK1-low CRC subset (Figure 4A and Supplementary Materials 6). Here, AKT1 is linked to colorectal carcinoma.