In addition, the NTRK3-high CRC subset, but not the NTRK3-low one, exhibited enrichment of PI3K-Akt, neurotrophin, ErbB, Ras, MAPK, chemokine and oestrogen signalling pathways, among others (Figure 4A and Supplementary Materials 8). The gene discussed is BDNF; the disease is colorectal carcinoma.