These data indicate the complex and dynamic regulation of CYP1B1 in bone sarcomas, which is consistent with the PPI map’s networked functions showing CYP1B1 as a key hub connecting detoxification, hormone, and xenobiotic metabolism through the cooperation of UGT family proteins, COMT, GSTP1, and others. The gene discussed is CYP1B1; the disease is bone sarcoma.