CXCR2 and neuroblastoma: In SH-SY5Y and NGP cells, cell cycle S phase was shown to be approximately 4.5 and 2.3 times lower than the control, respectively, when CXCR2 was inhibited by SB225002 (Figure 3C,D) Additionally, we found that SB225002 blocked NB cell cycle progression at the G2/M phase, which was evident by about a 5.6-fold increase in the percentage of cells in the G2/M phase in both SH-SY5Y and NGP cells (Figure 3C,D).