Furthermore, in tumor-associated neutrophils (TANs), CXCR2 mediates recruitment and protumor polarization, as N2 and SB225002 can have anti-tumor activity by inhibiting N2 TAN accumulation and enhance radiotherapy in nasopharyngeal carcinoma and synergizing with cisplatin in lung carcinomas [50]. Here, CXCR2 is linked to lung carcinoma.