In cerebral ischemia–reperfusion injury, seven days of Rh1 administration produced comprehensive neuroprotection, as evidenced by significantly improved neurological function scores, increased neuronal nuclei (NeuN)-positive neurons, elevated neurotrophic factors BDNF and nerve growth factor (NGF), and reduced oxidative stress markers—collectively demonstrating multi-target neuroprotective efficacy [145]. Here, NGF is linked to brain ischemia.