AR and Insulin resistance: Nobiletin decreased glucose, glycosylated hemoglobin (HbA1c), Homeostatic Model of Insulin Resistance (HOMA-IR), and pro-inflammatory cytokines expression, increased insulin, testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) expression, improved hyperglycemia, reduced pro-inflammatory cytokines, and augmented insulin, testosterone, LH, FSH and CYP17A1, reduced lipid peroxidation and improved the activity of the antioxidant enzymes and AR in testicular tissues of the diabetic group.