NOB significantly reduced hepatic lipid droplets and triglyceride levels and the expression of inflammatory factors (IFN-γ, TNF-α, IL-6, IL-1β, NF-κB, TLR2, and TLR4). It also improved glucose tolerance and insulin resistance, and decreased plasma insulin, free fatty acids, TC, non-HDL-C, and apolipoprotein B levels. The gene discussed is IL1B; the disease is Insulin resistance.