It attenuates diabetic encephalopathy by mitigating neuroinflammation and oxidative stress, protects against retinopathy by inhibiting MMP-9 and preserving retinal function, alleviates cardiomyopathy by reducing fibrosis and oxidative damage, prevents hepatopathy/NAFLD via metabolic reprogramming, and ameliorates nephropathy by suppressing inflammation and fibrosis. This evidence concerns the gene MMP9 and diabetic encephalopathy.