As obesity progresses, the adipokine secretion profile becomes imbalanced, with increases in pro-inflammatory molecules such as resistin, tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) among others and decreases in protective molecules like adiponectin, omentina-1, etc. [19]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.